› 4nni

X-ray diffraction
2.64Å resolution

Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide

Released:
DOI: 10.2210/pdb4nni/pdb
PDB 4nni coloured by chain and viewed from the front.
PDB 4nni coloured by chain and viewed from the side.
PDB 4nni coloured by chain and viewed from the top.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Yang J, Liu Y, Cai Q, Lin D

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
30S ribosomal protein S1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 161 amino acids
Theoretical weight: 18.58 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WH43 (Residues: 285-438; Coverage: 32%)
Gene names: MTCY01B2.22, Rv1630, rpsA
Sequence domains: S1 RNA binding domain

Ligands and Environments

1 bound ligand:
Ligand VGL 4 x VGL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P212121
Unit cell:
a: 66.506Å b: 66.593Å c: 127.162Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.255
Expression system: Escherichia coli

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Citations

7 review citations

Trans-Translation Is an Appealing Target for the Development of New Antimicrobial Compounds.
Campos-Silva et al. (2021)
6 more

3 mentions without citation

Synthesis of Novel Pyrazinamide Derivatives Based on 3-Chloropyrazine-2-carboxamide and Their Antimicrobial Evaluation.
Jandourek et al. (2017)
2 more