Function and Biology

Structure of Cid1 in complex with the UTP analog UMPNPP

Source organism: Schizosaccharomyces pombe
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.7.7.19: Polynucleotide adenylyltransferase

Reaction catalysed:
ATP + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
ATP:polynucleotide adenylyltransferase
Alternative Name(s):
  • AMP polynucleotidylexotransferase
  • ATP-polynucleotide adenylyltransferase
  • ATP:polynucleotidylexotransferase
  • Adenosine triphosphate:ribonucleic acid adenylyltransferase
  • NTP polymerase
  • Poly(A) hydrolase
  • Poly(A) polymerase
  • Poly(A) synthetase
  • Polyadenylate nucleotidyltransferase
  • Polyadenylate polymerase
  • Polyadenylate synthetase
  • Polyadenylic acid polymerase
  • Polyadenylic polymerase
  • RNA adenylating enzyme
  • RNA formation factors, PF1
  • Terminal riboadenylate transferase

EC 2.7.7.52: RNA uridylyltransferase

Reaction catalysed:
UTP + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
UTP:RNA uridylyltransferase
Alternative Name(s):
  • TUT
  • Terminal uridylyltransferase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF03828
Domain description: Cid1 family poly A polymerase
Occurring in:
  1. Terminal uridylyltransferase cid1
1 copy of Pfam domain PF03828 (Cid1 family poly A polymerase) in Terminal uridylyltransferase cid1 in PDB 4nkt.

PF01909
Domain description: Nucleotidyltransferase domain
Occurring in:
  1. Terminal uridylyltransferase cid1
1 copy of Pfam domain PF01909 (Nucleotidyltransferase domain) in Terminal uridylyltransferase cid1 in PDB 4nkt.

InterPro InterPro annotations
IPR002934
Domain description: Polymerase, nucleotidyl transferase domain
Occurring in:
  1. Terminal uridylyltransferase cid1
IPR002058
Domain description: PAP/25A-associated
Occurring in:
  1. Terminal uridylyltransferase cid1

Structure domains

CATH CATH domains
1.10.1410.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Poly(a)-polymerase, middle domain
Homology: Poly(a)-polymerase, middle domain
Occurring in:
  1. Terminal uridylyltransferase cid1
1 copy of CATH domain 1.10.1410.10 (Poly(a)-polymerase, middle domain) in Terminal uridylyltransferase cid1 in PDB 4nkt.
3.30.460.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Beta Polymerase; domain 2
Homology: Beta Polymerase, domain 2
Occurring in:
  1. Terminal uridylyltransferase cid1
1 copy of CATH domain 3.30.460.10 (Beta Polymerase; domain 2) in Terminal uridylyltransferase cid1 in PDB 4nkt.