Structure analysis

Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand

X-ray diffraction
2.01Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: hetero dimer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B
Length: 262 amino acids
Theoretical weight: 30.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51449 (Residues: 263-509; Coverage: 48%)
Gene names: NR1F3, RORC, RORG, RZRG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor

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Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.49 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-697; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

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