PDBe 4ni9

X-ray diffraction
2.55Å resolution

Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025), FORM 2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Interleukin-6 Chains: A, C
Molecule details ›
Chains: A, C
Length: 186 amino acids
Theoretical weight: 21.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05231 (Residues: 28-212; Coverage: 100%)
Gene names: IFNB2, IL6
Structure domains: Growth Hormone; Chain: A;
SOMAmer SL1025 Chains: B, D
Molecule details ›
Chains: B, D
Length: 32 nucleotides
Theoretical weight: 11.4 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P32
Unit cell:
a: 69.02Å b: 69.02Å c: 108.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.186 0.239
Expression systems:
  • Escherichia coli
  • Not provided