4ne6

X-ray diffraction
2.1Å resolution

Human MHF1-MHF2 complex

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-108754 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Centromere protein S Chains: A, C
Molecule details ›
Chains: A, C
Length: 93 amino acids
Theoretical weight: 10.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N2Z9 (Residues: 14-105; Coverage: 67%)
Gene names: APITD1, CENPS, FAAP16, MHF1
Sequence domains: CENP-S protein
Structure domains: Histone, subunit A
Centromere protein X Chains: B, D
Molecule details ›
Chains: B, D
Length: 74 amino acids
Theoretical weight: 8.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A8MT69 (Residues: 8-81; Coverage: 91%)
Gene names: CENPX, FAAP10, MHF2, STRA13
Sequence domains: CENP-S associating Centromere protein X
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P1
Unit cell:
a: 40.734Å b: 40.819Å c: 59.48Å
α: 91.9° β: 105.55° γ: 95.47°
R-values:
R R work R free
0.232 0.23 0.262
Expression system: Escherichia coli