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Human MHF1-MHF2 complex

X-ray diffraction
2.5Å resolution
PDB entry 4ne5 coloured by chain, front view.
PDB entry 4ne5 coloured by chain, side view.
PDB entry 4ne5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Centromere protein X and Centromere protein S
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Multimeric state: hetero tetramer
Accessible surface area: 17027.92 Å2
Buried surface area: 10811.55 Å2
Dissociation area: 745.77 Å2
Dissociation energy (ΔGdiss): 0.77 kcal/mol
Dissociation entropy (TΔSdiss): 12.26 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-108754
Assembly 2
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Assembly Name: Centromere protein X and Centromere protein S
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Multimeric state: hetero tetramer
Accessible surface area: 17034.77 Å2
Buried surface area: 10765.37 Å2
Dissociation area: 719.03 Å2
Dissociation energy (ΔGdiss): 0.33 kcal/mol
Dissociation entropy (TΔSdiss): 12.26 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-108754

Macromolecules

Centromere protein S
Chains: A, C, E, G
Length: 93 amino acids
Theoretical weight: 10.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8N2Z9 (Residues: 14-105; Coverage: 67%)
Gene names: APITD1, CENPS, FAAP16, MHF1
Pfam: CENP-S protein
InterPro:
CATH: Histone, subunit A
Centromere protein S in PDB entry 4ne5, assembly 1, front view.
Centromere protein S in PDB entry 4ne5, assembly 1, side view.
Centromere protein S in PDB entry 4ne5, assembly 1, top view.
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Centromere protein X
Chains: B, D, F, H
Length: 74 amino acids
Theoretical weight: 8.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A8MT69 (Residues: 8-81; Coverage: 91%)
Gene names: CENPX, FAAP10, MHF2, STRA13
Pfam: CENP-S associating Centromere protein X
InterPro: Centromere protein X
CATH:
Centromere protein X in PDB entry 4ne5, assembly 1, front view.
Centromere protein X in PDB entry 4ne5, assembly 1, side view.
Centromere protein X in PDB entry 4ne5, assembly 1, top view.
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