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Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122

Source organisms:
Biochemical function: not assigned
Biological process: not assigned
Cellular component: viral envelope

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00516
Domain description: Envelope glycoprotein GP120
Occurring in:
  1. Envelope glycoprotein gp160
The deposited structure of PDB entry 4nco contains 6 copies of Pfam domain PF00516 (Envelope glycoprotein GP120) in Envelope glycoprotein gp160. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. PGT122 light chain
  2. PGT122 heavy chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. PGT122 light chain
  2. PGT122 heavy chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. PGT122 light chain
  2. PGT122 heavy chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. PGT122 light chain
  2. PGT122 heavy chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. PGT122 light chain
  2. PGT122 heavy chain
IPR036377
Domain description: Gp120 core superfamily
Occurring in:
  1. Envelope glycoprotein gp160
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. PGT122 light chain
  2. PGT122 heavy chain
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. PGT122 light chain
  2. PGT122 heavy chain
IPR000777
Domain description: Human immunodeficiency virus 1, envelope glycoprotein Gp120
Occurring in:
  1. Envelope glycoprotein gp160

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