› 4n7e

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189211 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Sortilin Chain: A
Molecule details ›
Chain: A
Length: 696 amino acids
Theoretical weight: 77.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99523 (Residues: 78-756; Coverage: 85%)
Gene name: SORT1
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand PGE 1 x PGE
Ligand 2JQ 1 x 2JQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 161.948Å b: 77.402Å c: 111.176Å
α: 90° β: 127.06° γ: 90°
R-values:
R R work R free
0.204 0.201 0.242
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases.
Goettsch et al. (2018)
2 more