› 4n5g

X-ray diffraction
2.11Å resolution

Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012

Released:
DOI: 10.2210/pdb4n5g/pdb
PDB 4n5g coloured by chain and viewed from the front.
PDB 4n5g coloured by chain and viewed from the side.
PDB 4n5g coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Sulindac-Derived RXR�� Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site.
Chen L, Wang ZG, Aleshin AE, Chen F, Chen J, Jiang F, Alitongbieke G, Zeng Z, Ma Y, Huang M, Zhou H, Cadwell G, Zheng JF, Huang PQ, Liddington RC, Zhang XK, Su Y
Chem. Biol. (2014)
PMID: 24704507

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor RXR-alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 244 amino acids
Theoretical weight: 27.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 223-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand K09 2 x K09
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P21
Unit cell:
a: 46.585Å b: 98.83Å c: 110.579Å
α: 90° β: 99.02° γ: 90°
R-values:
R R work R free
0.201 0.199 0.247
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Overview of the structure-based non-genomic effects of the nuclear receptor RXRα.
Chen et al. (2018)
3 more

1 mention without citation

Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.
Chen et al. (2014)