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Crystal Structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (1-26)E10A

X-ray diffraction
1.88Å resolution
PDB entry 4n3a coloured by chain, front view.
PDB entry 4n3a coloured by chain, side view.
PDB entry 4n3a coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: HCF N-terminal chain 1 and UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
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Multimeric state: hetero dimer
Accessible surface area: 27886.21 Å2
Buried surface area: 2371.53 Å2
Dissociation area: 843.09 Å2
Dissociation energy (ΔGdiss): 1.72 kcal/mol
Dissociation entropy (TΔSdiss): 7.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127411

Macromolecules

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Chain: A
Length: 723 amino acids
Theoretical weight: 80.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15294 (Residues: 323-1041; Coverage: 69%)
Gene name: OGT
Pfam:
InterPro:
CATH:
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit in PDB entry 4n3a, assembly 1, front view.
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit in PDB entry 4n3a, assembly 1, side view.
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit in PDB entry 4n3a, assembly 1, top view.
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HCF C-terminal chain 2
Chain: B
Length: 26 amino acids
Theoretical weight: 2.64 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P51610 (Residues: 1072-1097; Coverage: 1%)
Gene names: HCF1, HCFC1, HFC1
HCF C-terminal chain 2 in PDB entry 4n3a, assembly 1, front view.
HCF C-terminal chain 2 in PDB entry 4n3a, assembly 1, side view.
HCF C-terminal chain 2 in PDB entry 4n3a, assembly 1, top view.
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