PDBe 4n19

X-ray diffraction
1.2Å resolution

Structural basis of conformational transitions in the active site and 80 s loop in the FK506 binding protein FKBP12

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP1A Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 11.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P62942 (Residues: 2-108)
Gene names: FKBP1, FKBP12, FKBP1A

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2
Unit cell:
a: 71.369Å b: 35.859Å c: 41.24Å
α: 90° β: 96.65° γ: 90°
R-values:
R R work R free
0.13 0.126 0.18
Expression system: Escherichia coli