› 4mvt

X-ray diffraction
2.3Å resolution

Crystal structure of SUMO E3 Ligase PIAS3

Released:
DOI: 10.2210/pdb4mvt/pdb
PDB 4mvt coloured by chain and viewed from the front.
PDB 4mvt coloured by chain and viewed from the side.
PDB 4mvt coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Dong A, Hu J, Li Y, Tempel W, Bountra C, Arrowsmith CH, Edwards AM, Tong Y, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 SUMO-protein ligase PIAS3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 374 amino acids
Theoretical weight: 41.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y6X2 (Residues: 112-467; Coverage: 57%)
Gene name: PIAS3
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand CL 2 x CL
Ligand UNX 32 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 55.45Å b: 85.44Å c: 89.53Å
α: 83.08° β: 86.57° γ: 86.14°
R-values:
R R work R free
0.239 0.238 0.27
Expression system: Escherichia coli BL21

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