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Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620

Source organisms:
Biochemical function: G protein-coupled acetylcholine receptor activity
Biological process: G protein-coupled receptor signaling pathway
Cellular component: membrane

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00001
Domain description: 7 transmembrane receptor (rhodopsin family)
Occurring in:
  1. Muscarinic acetylcholine receptor M2
The deposited structure of PDB entry 4mqt contains 1 copy of Pfam domain PF00001 (7 transmembrane receptor (rhodopsin family)) in Muscarinic acetylcholine receptor M2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000276
Domain description: G protein-coupled receptor, rhodopsin-like
Occurring in:
  1. Muscarinic acetylcholine receptor M2
IPR000995
Domain description: Muscarinic acetylcholine receptor family
Occurring in:
  1. Muscarinic acetylcholine receptor M2
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Nanobody 9-8
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Nanobody 9-8
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Nanobody 9-8
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Nanobody 9-8
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Nanobody 9-8
IPR017452
Domain description: GPCR, rhodopsin-like, 7TM
Occurring in:
  1. Muscarinic acetylcholine receptor M2

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Nanobody 9-8
The deposited structure of PDB entry 4mqt contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Nanobody 9-8. Showing 1 copy in chain B.
1.20.1070.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Rhopdopsin 7-helix transmembrane proteins
Homology: Rhodopsin 7-helix transmembrane proteins
Occurring in:
  1. Muscarinic acetylcholine receptor M2
The deposited structure of PDB entry 4mqt contains 1 copy of CATH domain 1.20.1070.10 (Rhopdopsin 7-helix transmembrane proteins) in Muscarinic acetylcholine receptor M2. Showing 1 copy in chain A.

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