PDBe 4mnx

X-ray diffraction
1.85Å resolution

Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK811

Source organism: Homo sapiens
Primary publication:
Peptide Ligands Stabilized by Small Molecules.
Angew. Chem. Int. Ed. Engl. (2014)
PMID: 24453110

Function and Biology Details

Reaction catalysed:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Urokinase-type plasminogen activator chain B Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 27.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: P00749 (Residues: 179-423; Coverage: 60%)
Gene name: PLAU
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
bicyclic peptide UK811 Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.57 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 52.45Å b: 53.5Å c: 79.58Å
α: 90° β: 90° γ: 90°
R R work R free
0.191 0.189 0.227
Expression systems:
  • Homo sapiens
  • Not provided