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Structural Basis for the MukB-topoisomerase IV Interaction

X-ray diffraction
2.3Å resolution
PDB entry 4mn4 coloured by chain, front view.
PDB entry 4mn4 coloured by chain, side view.
PDB entry 4mn4 coloured by chain, top view.
Source organism: Escherichia coli str. K-12 substr. MG1655
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Chromosome partition protein MukB and DNA topoisomerase 4 subunit A
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Multimeric state: hetero tetramer
Accessible surface area: 38999.35 Å2
Buried surface area: 5618.9 Å2
Dissociation area: 1,203.54 Å2
Dissociation energy (ΔGdiss): -19.28 kcal/mol
Dissociation entropy (TΔSdiss): 26.3 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-142728

Macromolecules

DNA topoisomerase 4 subunit A
Chains: A, B
Length: 259 amino acids
Theoretical weight: 28.3 KDa
Source organism: Escherichia coli str. K-12 substr. MG1655
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0AFI2 (Residues: 497-752; Coverage: 34%)
Gene names: JW2987, b3019, parC
Pfam: DNA gyrase C-terminal domain, beta-propeller
InterPro:
DNA topoisomerase 4 subunit A in PDB entry 4mn4, assembly 1, front view.
DNA topoisomerase 4 subunit A in PDB entry 4mn4, assembly 1, side view.
DNA topoisomerase 4 subunit A in PDB entry 4mn4, assembly 1, top view.
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Chromosome partition protein MukB
Chains: C, D
Length: 163 amino acids
Theoretical weight: 18.35 KDa
Source organism: Escherichia coli str. K-12 substr. MG1655
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22523 (Residues: 645-804; Coverage: 11%)
Gene names: JW0907, b0924, mukB
Pfam: MukB hinge domain
InterPro:
CATH:
Chromosome partition protein MukB in PDB entry 4mn4, assembly 1, front view.
Chromosome partition protein MukB in PDB entry 4mn4, assembly 1, side view.
Chromosome partition protein MukB in PDB entry 4mn4, assembly 1, top view.
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