› 4m9p

X-ray diffraction
1.72Å resolution

Crystal structure of the human filamin A Ig-like domains 3-5

Released:
DOI: 10.2210/pdb4m9p/pdb
PDB entry 4m9p coloured by chain, front view.
PDB entry 4m9p coloured by chain, side view.
PDB entry 4m9p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel structural unit in the N-terminal region of filamins.
Sethi R, Seppälä J, Tossavainen H, Ylilauri M, Ruskamo S, Pentikäinen OT, Pentikäinen U, Permi P, Ylänne J
J Biol Chem 289 8588-98 (2014)
PMID: 24469451

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Filamin-A Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 31.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P21333 (Residues: 478-766; Coverage: 11%)
Gene names: FLN, FLN1, FLNA
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P65
Unit cell:
a: 63.041Å b: 63.041Å c: 136.604Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.243
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

Structure and Function of Filamin C in the Muscle Z-Disc.
Mao et al. (2020)
6 other articles

8 mentions without citation

IRaPPA: information retrieval based integration of biophysical models for protein assembly selection.
Moal et al. (2017)
7 more