PDBe 4m6w

X-ray diffraction
2.9Å resolution

Crystal structure of the C-terminal segment of FANCM in complex with FAAP24

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fanconi anemia group M protein Chain: A
Molecule details ›
Chain: A
Length: 221 amino acids
Theoretical weight: 25.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IYD8 (Residues: 1813-2031; Coverage: 11%)
Gene names: FANCM, KIAA1596
Sequence domains: ERCC4 domain
Structure domains:
Fanconi anemia core complex-associated protein 24 Chain: B
Molecule details ›
Chain: B
Length: 208 amino acids
Theoretical weight: 23.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BTP7 (Residues: 17-215; Coverage: 93%)
Gene names: C19orf40, FAAP24
Sequence domains: Helix-hairpin-helix motif
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: I222
Unit cell:
a: 79.174Å b: 98.111Å c: 140.156Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.257 0.254 0.299
Expression system: Escherichia coli