PDBe 4m38

X-ray diffraction
2.2Å resolution

Crystal structure of Trypanosoma brucei protein arginine methyltransferase 7 complex with AdoHcy and histone H4 peptide


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein arginine N-methyltransferase 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 343 amino acids
Theoretical weight: 38.99 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli
  • Canonical: Q582G4 (Residues: 36-378; Coverage: 88%)
Gene names: PRMT7, Tb927.7.5490
Sequence domains: Ribosomal protein L11 methyltransferase (PrmA)
Structure domains:
Histone H4 Chains: E, F
Molecule details ›
Chains: E, F
Length: 21 amino acids
Theoretical weight: 2.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P62805 (Residues: 2-22; Coverage: 20%)
Gene names: H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 66.696Å b: 72.764Å c: 72.565Å
α: 90° β: 110.94° γ: 90°
R R work R free
0.19 0.188 0.23
Expression systems:
  • Escherichia coli
  • Not provided