X-ray diffraction
2.15Å resolution

Crystal structure of ITK in complex with compound 7 [4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide]


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase ITK/TSK Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 30.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q08881 (Residues: 354-620; Coverage: 43%)
Gene names: EMT, ITK, LYK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 40.25Å b: 68.87Å c: 49.45Å
α: 90° β: 106.56° γ: 90°
R R work R free
0.185 0.183 0.228
Expression system: Spodoptera frugiperda