PDBe 4lyf

X-ray diffraction
1.57Å resolution

Crystal Structure of small molecule vinylsulfonamide 8 covalently bound to K-Ras G12C


Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
GTPase KRas, N-terminally processed Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 170 amino acids
Theoretical weight: 19.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P01116 (Residues: 1-169; Coverage: 89%)
  • Best match: P01116-2 (Residues: 1-169)
Gene names: KRAS, KRAS2, RASK2
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: C2
Unit cell:
a: 68.265Å b: 83.835Å c: 86.186Å
α: 90° β: 110.9° γ: 90°
R R work R free
0.17 0.169 0.192
Expression system: Escherichia coli BL21(DE3)