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Crystal structure of broadly and potently neutralizing antibody VRC-CH31 in complex with HIV-1 clade A/E gp120 93TH057 with LOOP D and Loop V5 from clade A strain 3415_v1_c1

X-ray diffraction
2.25Å resolution
PDB entry 4lsq coloured by chain, front view.
PDB entry 4lsq coloured by chain, side view.
PDB entry 4lsq coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Envelope glycoprotein gp160 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 34928.93 Å2
Buried surface area: 10233.36 Å2
Dissociation area: 1,277 Å2
Dissociation energy (ΔGdiss): -1.32 kcal/mol
Dissociation entropy (TΔSdiss): 13.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-211974

Macromolecules

Envelope glycoprotein gp160
Chain: G
Length: 352 amino acids
Theoretical weight: 39.18 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q0ED31 (Residues: 43-486; Coverage: 41%)
Gene name: env
Pfam: Envelope glycoprotein GP120
InterPro:
CATH: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
Envelope glycoprotein gp160 in PDB entry 4lsq, assembly 1, front view.
Envelope glycoprotein gp160 in PDB entry 4lsq, assembly 1, side view.
Envelope glycoprotein gp160 in PDB entry 4lsq, assembly 1, top view.
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HEAVY CHAIN OF ANTIBODY VRC-CH31
Chain: H
Length: 236 amino acids
Theoretical weight: 25.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
CATH: Immunoglobulins
HEAVY CHAIN OF ANTIBODY VRC-CH31 in PDB entry 4lsq, assembly 1, front view.
HEAVY CHAIN OF ANTIBODY VRC-CH31 in PDB entry 4lsq, assembly 1, side view.
HEAVY CHAIN OF ANTIBODY VRC-CH31 in PDB entry 4lsq, assembly 1, top view.
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LIGHT CHAIN OF ANTIBODY VRC-CH31 WITH N70D MUTATION
Chain: L
Length: 210 amino acids
Theoretical weight: 22.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
CATH: Immunoglobulins
LIGHT CHAIN OF ANTIBODY VRC-CH31 WITH N70D MUTATION in PDB entry 4lsq, assembly 1, front view.
LIGHT CHAIN OF ANTIBODY VRC-CH31 WITH N70D MUTATION in PDB entry 4lsq, assembly 1, side view.
LIGHT CHAIN OF ANTIBODY VRC-CH31 WITH N70D MUTATION in PDB entry 4lsq, assembly 1, top view.
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