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The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: signal transduction
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13676
Domain description: TIR domain
Occurring in:
  1. Toll/interleukin-1 receptor domain-containing adapter protein
The deposited structure of PDB entry 4lqd contains 1 copy of Pfam domain PF13676 (TIR domain) in Toll/interleukin-1 receptor domain-containing adapter protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000157
Domain description: Toll/interleukin-1 receptor homology (TIR) domain
Occurring in:
  1. Toll/interleukin-1 receptor domain-containing adapter protein
IPR035897
Domain description: Toll/interleukin-1 receptor homology (TIR) domain superfamily
Occurring in:
  1. Toll/interleukin-1 receptor domain-containing adapter protein
IPR017279
Domain description: Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
Occurring in:
  1. Toll/interleukin-1 receptor domain-containing adapter protein

Structure domain

CATH CATH domain
3.40.50.10140
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Toll/interleukin-1 receptor homology (TIR) domain
Occurring in:
  1. Toll/interleukin-1 receptor domain-containing adapter protein
The deposited structure of PDB entry 4lqd contains 1 copy of CATH domain 3.40.50.10140 (Rossmann fold) in Toll/interleukin-1 receptor domain-containing adapter protein. Showing 1 copy in chain A.

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