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Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate)

X-ray diffraction
2.319Å resolution
PDB entry 4loq coloured by chain, front view.
PDB entry 4loq coloured by chain, side view.
PDB entry 4loq coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 and Mitogen-activated protein kinase 14
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Multimeric state: hetero dimer
Accessible surface area: 18148.77 Å2
Buried surface area: 3290.66 Å2
Dissociation area: 1,023.38 Å2
Dissociation energy (ΔGdiss): 13.42 kcal/mol
Dissociation entropy (TΔSdiss): 9.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155655
Assembly 2
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Assembly Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 and Mitogen-activated protein kinase 14
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Multimeric state: hetero dimer
Accessible surface area: 18362.23 Å2
Buried surface area: 4203.28 Å2
Dissociation area: 1,248.05 Å2
Dissociation energy (ΔGdiss): 11.25 kcal/mol
Dissociation entropy (TΔSdiss): 9.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155655
Assembly 3
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Assembly Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 and Mitogen-activated protein kinase 14
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Multimeric state: hetero dimer
Accessible surface area: 17862.0 Å2
Buried surface area: 3836.6 Å2
Dissociation area: 1,270.93 Å2
Dissociation energy (ΔGdiss): 11.33 kcal/mol
Dissociation entropy (TΔSdiss): 9.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155655
Assembly 4
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Assembly Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 and Mitogen-activated protein kinase 14
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Multimeric state: hetero dimer
Accessible surface area: 17949.67 Å2
Buried surface area: 3430.76 Å2
Dissociation area: 1,042.17 Å2
Dissociation energy (ΔGdiss): 13.22 kcal/mol
Dissociation entropy (TΔSdiss): 9.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155655

Macromolecules

Mitogen-activated protein kinase 14
Chains: A, B, C, D
Length: 361 amino acids
Theoretical weight: 41.4 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47811 (Residues: 1-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Pfam: Protein kinase domain
InterPro:
CATH:
Mitogen-activated protein kinase 14 in PDB entry 4loq, assembly 1, front view.
Mitogen-activated protein kinase 14 in PDB entry 4loq, assembly 1, side view.
Mitogen-activated protein kinase 14 in PDB entry 4loq, assembly 1, top view.
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TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Chains: K, L, M, N
Length: 29 amino acids
Theoretical weight: 3.1 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q8CF89 (Residues: 384-412; Coverage: 6%)
Gene names: Map3k7ip1, Tab1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 in PDB entry 4loq, assembly 1, front view.
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 in PDB entry 4loq, assembly 1, side view.
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 in PDB entry 4loq, assembly 1, top view.
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