4lmo

X-ray diffraction
2.37Å resolution

Structure of a vertebrate RNA binding domain of telomerase (TRBD)

Released:

Function and Biology Details

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Telomerase reverse transcriptase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 254 amino acids
Theoretical weight: 29.76 KDa
Source organism: Takifugu rubripes
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4KTA7 (Residues: 294-544; Coverage: 23%)
Gene name: tert
Sequence domains: Telomerase ribonucleoprotein complex - RNA binding domain
Structure domains: Topoisomerase I; Chain A, domain 4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25, null
Spacegroup: P21
Unit cell:
a: 48.629Å b: 84.508Å c: 137.174Å
α: 90° β: 94.31° γ: 90°
R-values:
R R work R free
0.222 0.22 0.259
Expression system: Escherichia coli