X-ray diffraction
2.36Å resolution

Structure of mouse cGAS bound to an 18bp DNA and cGAS product


Function and Biology Details

Reaction catalysed:
(1a) ATP + GTP = pppG-P(2'-5')A + diphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Cyclic GMP-AMP synthase Chains: A, C
Molecule details ›
Chains: A, C
Length: 366 amino acids
Theoretical weight: 42.98 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: Q8C6L5 (Residues: 142-507; Coverage: 72%)
Gene names: Cgas, Mb21d1
Sequence domains:
Structure domains:
18bp dsDNA Chains: E, F, I, J
Molecule details ›
Chains: E, F, I, J
Length: 18 nucleotides
Theoretical weight: 5.51 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 79.209Å b: 99.031Å c: 142.631Å
α: 90° β: 90° γ: 90°
R R work R free
0.195 0.192 0.247
Expression systems:
  • Escherichia coli
  • Not provided