› 4l8t

X-ray diffraction
2.95Å resolution

Structure of the Cargo Binding Domain from Human Myosin Vc

Released:
DOI: 10.2210/pdb4l8t/pdb
PDB entry 4l8t coloured by chain, front view.
PDB entry 4l8t coloured by chain, side view.
PDB entry 4l8t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into functional overlapping and differentiation among myosin V motors.
Nascimento AFZ, Trindade DM, Tonoli CCC, de Giuseppe PO, Assis LHP, Honorato RV, de Oliveira PSL, Mahajan P, Burgess-Brown NA, von Delft F, Larson RE, Murakami MT
J Biol Chem 288 34131-34145 (2013)
PMID: 24097982

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192522 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-Vc Chain: A
Molecule details ›
Chain: A
Length: 447 amino acids
Theoretical weight: 51.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NQX4 (Residues: 1319-1742; Coverage: 24%)
Gene name: MYO5C
Sequence domains: DIL domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: P4122
Unit cell:
a: 116.399Å b: 116.399Å c: 114.752Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.222 0.274
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Myosin-Driven Intracellular Transport.
Titus MA. (2018)
6 more

2 mentions without citation

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes.
Pylypenko et al. (2016)
1 more