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Crystal structure of a bile-acid 7-alpha dehydratase (CLOHYLEM_06634) from Clostridium hylemonae DSM 15053 at 2.20 A resolution

Source organism: [Clostridium] hylemonae DSM 15053
Biochemical function: lyase activity
Biological process: not assigned
Cellular component: not assigned

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EC 4.2.1.106: Bile-acid 7-alpha-dehydratase

Reaction catalysed:
7-alpha,12-alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12-alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(2)O
Systematic name:
7-alpha,12-alpha-dihydroxy-3-oxochol-4-enoyl-CoA hydro-lyase (12-alpha-hydroxy-3-oxochola-4,6-dienoyl-CoA-forming)
Alternative Name(s):
  • 7-alpha,12-alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase
  • 7-alpha,12-alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12-alpha-hydroxy-3-oxochola-4,6-dienoate-forming)
  • BA7 alpha dehydratase
  • BaiE (gene name)

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13577
Domain description: SnoaL-like domain
Occurring in:
  1. SnoaL-like domain-containing protein
1 copy of Pfam domain PF13577 (SnoaL-like domain) in SnoaL-like domain-containing protein in PDB 4l8o.

InterPro InterPro annotations
IPR032710
Domain description: NTF2-like domain superfamily
Occurring in:
  1. SnoaL-like domain-containing protein
IPR037401
Domain description: SnoaL-like domain
Occurring in:
  1. SnoaL-like domain-containing protein

Structure domain

CATH CATH domain
3.10.450.50
Class: Alpha Beta
Architecture: Roll
Topology: Nuclear Transport Factor 2; Chain: A,
Homology: Nuclear Transport Factor 2; Chain: A,
Occurring in:
  1. SnoaL-like domain-containing protein
1 copy of CATH domain 3.10.450.50 (Nuclear Transport Factor 2; Chain: A,) in SnoaL-like domain-containing protein in PDB 4l8o.

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