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Crystal Structure of Ketosteroid Isomerase D38E from Pseudomonas Testosteroni (tKSI)

Source organism: Comamonas testosteroni
Biochemical function: isomerase activity
Biological process: steroid metabolic process
Cellular component: not assigned

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EC 5.3.3.1: Steroid Delta-isomerase

Reaction catalysed:
A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid
Systematic name:
3-oxosteroid Delta(5)-Delta(4)-isomerase
Alternative Name(s):
  • 3-oxosteroid isomerase
  • Delta(5)(or Delta(4))-3-keto steroid isomerase
  • Delta(5)-3-keto steroid isomerase
  • Delta(5)-3-ketosteroid isomerase
  • Delta(5)-3-oxosteroid isomerase
  • Delta(5)-ketosteroid isomerase
  • Delta(5)-steroid isomerase
  • Hydroxysteroid isomerase
  • Steroid isomerase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02136
Domain description: Nuclear transport factor 2 (NTF2) domain
Occurring in:
  1. Steroid Delta-isomerase
The deposited structure of PDB entry 4l7k contains 12 copies of Pfam domain PF02136 (Nuclear transport factor 2 (NTF2) domain) in Steroid Delta-isomerase. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR002075
Domain description: Nuclear transport factor 2 domain
Occurring in:
  1. Steroid Delta-isomerase
IPR011944
Domain description: Steroid delta5-4-isomerase
Occurring in:
  1. Steroid Delta-isomerase
IPR039256
Domain description: Ketosteroid isomerase
Occurring in:
  1. Steroid Delta-isomerase
IPR032710
Domain description: NTF2-like domain superfamily
Occurring in:
  1. Steroid Delta-isomerase

Structure domain

CATH CATH domain
3.10.450.50
Class: Alpha Beta
Architecture: Roll
Topology: Nuclear Transport Factor 2; Chain: A,
Homology: Nuclear Transport Factor 2; Chain: A,
Occurring in:
  1. Steroid Delta-isomerase
The deposited structure of PDB entry 4l7k contains 12 copies of CATH domain 3.10.450.50 (Nuclear Transport Factor 2; Chain: A,) in Steroid Delta-isomerase. Showing 1 copy in chain C.

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