X-ray diffraction
2.1Å resolution

Structural Characterisation of the Apo-form of Human Lactate Dehydrogenase M Isozyme

Source organism: Homo sapiens
Primary publication:
Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase.
OpenAccess logo Acta Crystallogr D Biol Crystallogr 70 1484-90 (2014)
PMID: 24816116

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
L-lactate dehydrogenase A chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 339 amino acids
Theoretical weight: 37.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P00338 (Residues: 2-332; Coverage: 100%)
Gene names: LDHA, PIG19
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P4122
Unit cell:
a: 84.652Å b: 84.652Å c: 275.969Å
α: 90° β: 90° γ: 90°
R R work R free
0.165 0.164 0.182
Expression system: Escherichia coli