› 4l43

X-ray diffraction
3Å resolution

Crystal structures of human p70S6K1-T389A (form I)

Released:
DOI: 10.2210/pdb4l43/pdb
PDB entry 4l43 coloured by chain, front view.
PDB entry 4l43 coloured by chain, side view.
PDB entry 4l43 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif.
Wang J, Zhong C, Wang F, Qu F, Ding J
Biochem J 454 39-47 (2013)
PMID: 23731517

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase beta-1 Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 38.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23443 (Residues: 75-417; Coverage: 65%)
Gene names: RPS6KB1, STK14A
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 5FI 1 x 5FI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3221
Unit cell:
a: 79.572Å b: 79.572Å c: 112.749Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.227 0.279
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Hypoxia and aging.
Yeo EJ. (2019)
3 more

1 mention without citation

Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways.
Xu et al. (2023)