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Crystal Structure of 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine bound to TAK1-TAB1

X-ray diffraction
2.68Å resolution
PDB entry 4l3p coloured by chain, front view.
PDB entry 4l3p coloured by chain, side view.
PDB entry 4l3p coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
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Multimeric state: monomeric
Accessible surface area: 14281.09 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-128894

Macromolecules

Mitogen-activated protein kinase kinase kinase 7; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Chain: A
Length: 315 amino acids
Theoretical weight: 35.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43318 (Residues: 31-303; Coverage: 45%)
  • Canonical: Q15750 (Residues: 468-504; Coverage: 7%)
    • nullnull
Gene names: MAP3K7, MAP3K7IP1, TAB1, TAK1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Mitogen-activated protein kinase kinase kinase 7 in PDB entry 4l3p, assembly 1, front view.
Mitogen-activated protein kinase kinase kinase 7 in PDB entry 4l3p, assembly 1, side view.
Mitogen-activated protein kinase kinase kinase 7 in PDB entry 4l3p, assembly 1, top view.
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