X-ray diffraction
2.29Å resolution

Structure of human ARGONAUTE1 in complex with guide RNA


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Protein argonaute-1 Chain: A
Molecule details ›
Chain: A
Length: 862 amino acids
Theoretical weight: 97.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q9UL18 (Residues: 1-857; Coverage: 100%)
Gene names: AGO1, EIF2C1
Sequence domains:
Structure domains:
RNA Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.86 KDa
Source organism: Spodoptera frugiperda

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 69.879Å b: 100.249Å c: 136.701Å
α: 90° β: 90° γ: 90°
R R work R free
0.177 0.175 0.228
Expression system: Spodoptera frugiperda