4kv5

X-ray diffraction
3Å resolution

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transforming growth factor beta-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 112 amino acids
Theoretical weight: 12.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01137 (Residues: 279-390; Coverage: 31%)
Gene names: TGFB, TGFB1
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Single-chain variable fragment GC1009 Chains: E, G, H, J
Molecule details ›
Chains: E, G, H, J
Length: 252 amino acids
Theoretical weight: 26.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 108.188Å b: 171.769Å c: 109.876Å
α: 90° β: 111.3° γ: 90°
R-values:
R R work R free
0.233 0.229 0.3
Expression system: Escherichia coli