› › Function and Biology

Crystal Structure of Pho85-Pcl10-ATP-gamma-S Complex

Source organism: Saccharomyces cerevisiae S288C
Biochemical function: protein kinase binding
Biological process: regulation of cyclin-dependent protein serine/threonine kinase activity
Cellular component: Pho85-Pho80 CDK-cyclin complex

Quick links

EC 2.7.11.22: Cyclin-dependent kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:cyclin phosphotransferase
Alternative Name(s):
  • Bur1
  • Bur1 Cdk
  • CDK
  • Cak1
  • Cak1p
  • Cdc2
  • Cdc2 kinase
  • Cdc28p
  • Cdk-activating kinase
  • Cdk-activating protein kinase
  • Cdk1
  • Cdk2
  • Cdk2
  • Cdk3
  • Cdk4
  • Cdk5
  • Cdk6
  • Cdk7
  • Cdk8
  • Cdk9
  • Cyclin A-activated cdc2
  • Cyclin A-activated cdk2
  • Cyclin D-cdk6 kinase
  • Cyclin D-dependent kinase
  • Cyclin E kinase
  • Cyclin-A associated kinase
  • Cyclin-dependent kinase 6
  • Cyclin-dependent kinase-2
  • Cyclin-dependent kinase-4
  • Cyclin-dependent protein kinase activating kinase
  • Cyk
  • D-type cyclin kinase
  • Nclk
  • Neuronal cdc2-like kinase
  • PCTAIRE-1
  • STK25

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF08613
Domain description: Cyclin
Occurring in:
  1. PHO85 cyclin-10
The deposited structure of PDB entry 4krc contains 1 copy of Pfam domain PF08613 (Cyclin) in PHO85 cyclin-10. Showing 1 copy in chain B.

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Cyclin-dependent protein kinase PHO85
The deposited structure of PDB entry 4krc contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Cyclin-dependent protein kinase PHO85. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013922
Domain description: Cyclin PHO80-like
Occurring in:
  1. PHO85 cyclin-10
IPR036915
Domain description: Cyclin-like superfamily
Occurring in:
  1. PHO85 cyclin-10
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Cyclin-dependent protein kinase PHO85
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Cyclin-dependent protein kinase PHO85
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Cyclin-dependent protein kinase PHO85
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Cyclin-dependent protein kinase PHO85

Structure domains

CATH CATH domains
1.10.472.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cyclin A; domain 1
Homology: Cyclin-like
Occurring in:
  1. PHO85 cyclin-10
The deposited structure of PDB entry 4krc contains 1 copy of CATH domain 1.10.472.10 (Cyclin A; domain 1) in PHO85 cyclin-10. Showing 1 copy in chain B.
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Cyclin-dependent protein kinase PHO85
The deposited structure of PDB entry 4krc contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Cyclin-dependent protein kinase PHO85. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Cyclin-dependent protein kinase PHO85
The deposited structure of PDB entry 4krc contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Cyclin-dependent protein kinase PHO85. Showing 1 copy in chain A.

Quick links