EC 1.14.14.14: Aromatase
Reaction catalysed:
(1a) testosterone + [reduced NADPH--hemoprotein reductase] + O(2) = 19-hydroxytestosterone + H(2)O + [oxidized NADPH--hemoprotein reductase]
Systematic name:
Testosterone monooxygenase (17-beta-estradiol-forming)
Alternative Name(s):
- CYP19A1
- Estrogen synthetase
GO terms
Biochemical function:
- aromatase activity
- metal ion binding
- heme binding
- oxygen binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- oxidoreductase activity
- electron transfer activity
- steroid hydroxylase activity
- iron ion binding
- monooxygenase activity
Biological process:
- positive regulation of estradiol secretion
- testosterone biosynthetic process
- prostate gland growth
- uterus development
- response to estradiol
- mammary gland development
- female genitalia development
- sterol metabolic process
- negative regulation of macrophage chemotaxis
- female gonad development
- androgen metabolic process
- syncytium formation
- androgen catabolic process
- estrogen biosynthetic process
- steroid biosynthetic process
- lipid metabolic process
- negative regulation of chronic inflammatory response
Protein family (Pfam)
InterPro annotations
CATH domain