PDBe 4kq8

X-ray diffraction
3.29Å resolution

Structure of Recombinant Human Cytochrome P450 Aromatase

Released:

Function and Biology Details

Reaction catalysed:
(1a) testosterone + [reduced NADPH--hemoprotein reductase] + O(2) = 19-hydroxytestosterone + H(2)O + [oxidized NADPH--hemoprotein reductase]
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aromatase Chain: A
Molecule details ›
Chain: A
Length: 473 amino acids
Theoretical weight: 54.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11511 (Residues: 45-503; Coverage: 91%)
Gene names: ARO1, CYAR, CYP19, CYP19A1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 140.821Å b: 140.821Å c: 116.477Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.216 0.248
Expression system: Escherichia coli