› 4km7

X-ray diffraction
1.8Å resolution

Human folate receptor alpha (FOLR1) at acidic pH, triclinic form

Released:
DOI: 10.2210/pdb4km7/pdb
PDB entry 4km7 coloured by chain, front view.
PDB entry 4km7 coloured by chain, side view.
PDB entry 4km7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.
Wibowo AS, Singh M, Reeder KM, Carter JJ, Kovach AR, Meng W, Ratnam M, Zhang F, Dann CE
Proc Natl Acad Sci U S A 110 15180-8 (2013)
PMID: 23934049

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147318 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Folate receptor alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 207 amino acids
Theoretical weight: 24.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P15328 (Residues: 28-234; Coverage: 89%)
Gene names: FOLR, FOLR1
Sequence domains: Folate receptor family

Ligands and Environments

2 bound ligands:
Ligand K 2 x K
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P1
Unit cell:
a: 33.709Å b: 55.384Å c: 69.504Å
α: 72.23° β: 86.95° γ: 90.12°
R-values:
R R work R free
0.224 0.222 0.269
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

The folate receptor as a rational therapeutic target for personalized cancer treatment.
Assaraf et al. (2014)
13 more

1 mention without citation

Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.
Wibowo et al. (2013)