› 4kk7

X-ray diffraction
1.68Å resolution

Structure of EccB1 from the type VII (ESX-1) secretion system of Mycobacterium tuberculosis.

Released:
DOI: 10.2210/pdb4kk7/pdb
PDB 4kk7 coloured by chain and viewed from the front.
PDB 4kk7 coloured by chain and viewed from the side.
PDB 4kk7 coloured by chain and viewed from the top.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Wagner JM, Chan S, Evans TJ, Kahng S, Kim J, Arbing MA, Eisenberg D, Korotkov KV
OpenAccess logo BMC Struct Biol 16 5 (2016)
PMID: 26922638

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ESX-1 secretion system protein eccB1 Chain: A
Molecule details ›
Chain: A
Length: 395 amino acids
Theoretical weight: 41.83 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NI 4 x NI
Ligand TRS 1 x TRS
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 31.7Å b: 110.63Å c: 110.51Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.214
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Mycobacterial Virulence Factors: Surface-Exposed Lipids and Secreted Proteins.
Ly et al. (2020)
1 more

2 mentions without citation

Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Wagner et al. (2016)
1 more