PDBe 4kgj

X-ray diffraction
2.99Å resolution

Crystal structure of human alpha-L-iduronidase complex with 5-fluoro-alpha-L-idopyranosyluronic acid fluoride


Function and Biology Details

Reaction catalysed:
Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Alpha-L-iduronidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 627 amino acids
Theoretical weight: 70.05 KDa
Source organism: Homo sapiens
Expression system: Arabidopsis thaliana
  • Canonical: P35475 (Residues: 27-653; Coverage: 100%)
Gene name: IDUA
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: R3
Unit cell:
a: 259.343Å b: 259.343Å c: 71.379Å
α: 90° β: 90° γ: 120°
R R work R free
0.18 0.178 0.227
Expression system: Arabidopsis thaliana