X-ray diffraction
2.1Å resolution

CK1d in complex with (3S)-3-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]pyridin-2-yl}morpholine inhibitor


Function and Biology Details

Reactions catalysed:
ATP + [tau protein] = ADP + [tau protein] phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Casein kinase I isoform delta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 331 amino acids
Theoretical weight: 38.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P48730 (Residues: 3-317; Coverage: 76%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P1
Unit cell:
a: 49.103Å b: 84.76Å c: 89.447Å
α: 108.06° β: 105.85° γ: 93.09°
R R work R free
0.193 0.191 0.225
Expression system: Spodoptera frugiperda