X-ray diffraction
1.98Å resolution

CK1d in complex with {4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDIN-2-YL}METHANOL inhibitor


Function and Biology Details

Reactions catalysed:
ATP + [tau protein] = ADP + [tau protein] phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Casein kinase I isoform delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 317 amino acids
Theoretical weight: 37 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P48730 (Residues: 1-317; Coverage: 76%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 56.58Å b: 118.14Å c: 61.22Å
α: 90° β: 109.23° γ: 90°
R R work R free
0.186 0.185 0.215
Expression system: Spodoptera frugiperda