› 4k7a

X-ray diffraction
2.44Å resolution

Crystal structure of the androgen receptor ligand binding domain in complex with minoxidil

Released:
DOI: 10.2210/pdb4k7a/pdb
PDB 4k7a coloured by chain and viewed from the front.
PDB 4k7a coloured by chain and viewed from the side.
PDB 4k7a coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Liu JS, Hsu CL, Wu WG

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 28.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10275 (Residues: 671-919; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand DHT 1 x DHT
Ligand MXD 1 x MXD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P212121
Unit cell:
a: 55.429Å b: 65.541Å c: 70.384Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.188 0.268
Expression system: Escherichia coli

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