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Crystal structure of a single cambialistic SOD2 occupied by Manganese ion from Clostridium difficile

Source organism: Clostridioides difficile 630
Biochemical function: metal ion binding
Biological process: removal of superoxide radicals
Cellular component: not assigned

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EC 1.15.1.1: Superoxide dismutase

Reaction catalysed:
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Systematic name:
Superoxide:superoxide oxidoreductase
Alternative Name(s):
  • Copper-zinc superoxide dismutase
  • Cu,Zn-SOD
  • Cu-Zn superoxide dismutase
  • Cuprein
  • Cytocuprein
  • Erythrocuprein
  • Fe-SOD
  • Ferrisuperoxide dismutase
  • Hemocuprein
  • Hepatocuprein
  • Mn-SOD
  • SOD
  • SOD-1
  • SOD-2
  • SOD-3
  • SOD-4
  • SODF
  • SODS
  • Superoxidase dismutase
  • Superoxide dismutase I
  • Superoxide dismutase II

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02777
Domain description: Iron/manganese superoxide dismutases, C-terminal domain
Occurring in:
  1. Superoxide dismutase
The deposited structure of PDB entry 4jzg contains 1 copy of Pfam domain PF02777 (Iron/manganese superoxide dismutases, C-terminal domain) in Superoxide dismutase. Showing 1 copy in chain A.

PF00081
Domain description: Iron/manganese superoxide dismutases, alpha-hairpin domain
Occurring in:
  1. Superoxide dismutase
The deposited structure of PDB entry 4jzg contains 1 copy of Pfam domain PF00081 (Iron/manganese superoxide dismutases, alpha-hairpin domain) in Superoxide dismutase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001189
Domain description: Manganese/iron superoxide dismutase
Occurring in:
  1. Superoxide dismutase
IPR036314
Domain description: Manganese/iron superoxide dismutase, C-terminal domain superfamily
Occurring in:
  1. Superoxide dismutase
IPR036324
Domain description: Manganese/iron superoxide dismutase, N-terminal domain superfamily
Occurring in:
  1. Superoxide dismutase
IPR019833
Domain description: Manganese/iron superoxide dismutase, binding site
Occurring in:
  1. Superoxide dismutase
IPR019832
Domain description: Manganese/iron superoxide dismutase, C-terminal
Occurring in:
  1. Superoxide dismutase
IPR019831
Domain description: Manganese/iron superoxide dismutase, N-terminal
Occurring in:
  1. Superoxide dismutase

Structure domains

CATH CATH domains
3.55.40.20
Class: Alpha Beta
Architecture: 3-Layer(bab) Sandwich
Topology: minor pseudopilin epsh fold
Homology: Iron/manganese superoxide dismutase, C-terminal domain
Occurring in:
  1. Superoxide dismutase
The deposited structure of PDB entry 4jzg contains 1 copy of CATH domain 3.55.40.20 (minor pseudopilin epsh fold) in Superoxide dismutase. Showing 1 copy in chain A.
1.10.287.990
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Fe,Mn superoxide dismutase (SOD) domain
Occurring in:
  1. Superoxide dismutase
The deposited structure of PDB entry 4jzg contains 1 copy of CATH domain 1.10.287.990 (Helix Hairpins) in Superoxide dismutase. Showing 1 copy in chain A.

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