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CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD

Source organism: Homo sapiens
Biochemical function: DNA binding
Biological process: transcription by RNA polymerase II
Cellular component: not assigned

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EC 2.7.7.6: DNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • C RNA formation factors
  • C ribonucleic acid formation factors
  • DNA-dependent RNA nucleotidyltransferase
  • DNA-dependent RNA polymerase
  • DNA-dependent ribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid-dependent ribonucleic acid polymerase
  • RNA nucleotidyltransferase
  • RNA nucleotidyltransferase (DNA-directed)
  • RNA polymerase
  • RNA polymerase I
  • RNA polymerase II
  • RNA polymerase III
  • RNA transcriptase
  • Ribonucleate nucleotidyltransferase
  • Ribonucleate polymerase
  • Ribonucleic acid nucleotidyltransferase
  • Ribonucleic acid polymerase
  • Ribonucleic acid transcriptase
  • Ribonucleic polymerase
  • Ribonucleic transcriptase
  • Transcriptase

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF05001
Domain description: RNA polymerase Rpb1 C-terminal repeat
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 4jxt contains 2 copies of Pfam domain PF05001 (RNA polymerase Rpb1 C-terminal repeat ) in DNA-directed RNA polymerase II subunit RPB1. Showing 2 copies in chain B.

PF04818
Domain description: CID domain
Occurring in:
  1. Regulation of nuclear pre-mRNA domain-containing protein 1A
The deposited structure of PDB entry 4jxt contains 1 copy of Pfam domain PF04818 (CID domain) in Regulation of nuclear pre-mRNA domain-containing protein 1A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006569
Domain description: CID domain
Occurring in:
  1. Regulation of nuclear pre-mRNA domain-containing protein 1A
IPR000684
Domain description: RNA polymerase II, heptapeptide repeat, eukaryotic
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR008942
Domain description: ENTH/VHS
Occurring in:
  1. Regulation of nuclear pre-mRNA domain-containing protein 1A
IPR047884
Domain description: RPRD1A, CID domain
Occurring in:
  1. Regulation of nuclear pre-mRNA domain-containing protein 1A

Structure domain

CATH CATH domain
1.25.40.90
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Occurring in:
  1. Regulation of nuclear pre-mRNA domain-containing protein 1A
The deposited structure of PDB entry 4jxt contains 1 copy of CATH domain 1.25.40.90 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Regulation of nuclear pre-mRNA domain-containing protein 1A. Showing 1 copy in chain A.

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