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Crystal structure of a mutant fragment of Human HSPB6

X-ray diffraction
2.196Å resolution
PDB entry 4jut coloured by chain, front view.
PDB entry 4jut coloured by chain, side view.
PDB entry 4jut coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Heat shock protein beta-6
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Multimeric state: homo tetramer
Accessible surface area: 17813.99 Å2
Buried surface area: 8280.9 Å2
Dissociation area: 3,879.65 Å2
Dissociation energy (ΔGdiss): 23.74 kcal/mol
Dissociation entropy (TΔSdiss): 34.67 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127007
Assembly 2
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Assembly Name: Heat shock protein beta-6
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Multimeric state: homo tetramer
Accessible surface area: 18995.24 Å2
Buried surface area: 7586.95 Å2
Dissociation area: 3,540.1 Å2
Dissociation energy (ΔGdiss): 18.7 kcal/mol
Dissociation entropy (TΔSdiss): 34.68 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127007

Macromolecules

Heat shock protein beta-6
Chains: A, B, C, D, E, F, G, H
Length: 107 amino acids
Theoretical weight: 11.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14558 (Residues: 57-160; Coverage: 65%)
Gene name: HSPB6
Pfam: Hsp20/alpha crystallin family
InterPro:
CATH: Immunoglobulin-like
Heat shock protein beta-6 in PDB entry 4jut, assembly 1, front view.
Heat shock protein beta-6 in PDB entry 4jut, assembly 1, side view.
Heat shock protein beta-6 in PDB entry 4jut, assembly 1, top view.
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