› 4jmj

X-ray diffraction
2.38Å resolution

Structure of dusp11

Released:
DOI: 10.2210/pdb4jmj/pdb
PDB entry 4jmj coloured by chain, front view.
PDB entry 4jmj coloured by chain, side view.
PDB entry 4jmj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The family-wide structure and function of human dual-specificity protein phosphatases.
Jeong DG, Wei CH, Ku B, Jeon TJ, Chien PN, Kim JK, Park SY, Hwang HS, Ryu SY, Park H, Kim DS, Kim SJ, Ryu SE
Acta Crystallogr D Biol Crystallogr 70 421-35 (2014)
PMID: 24531476

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130893 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA/RNP complex-1-interacting phosphatase Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 21.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75319 (Residues: 28-208; Coverage: 55%)
Gene names: DUSP11, PIR1
Sequence domains: Dual specificity phosphatase, catalytic domain
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:
Ligand PO4 1 x PO4
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6B
Spacegroup: P63
Unit cell:
a: 94.779Å b: 94.779Å c: 44.304Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.178 0.219
Expression system: Escherichia coli

Quick links

Citations

3 review citations

To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling.
Javadpour et al. (2019)
2 more