Structure analysis

SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy

X-ray diffraction
1.59Å resolution
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 11427.83 Å2
Buried surface area: 1222.84 Å2
Dissociation area: 611.42 Å2
Dissociation energy (ΔGdiss): 0.72 kcal/mol
Dissociation entropy (TΔSdiss): 6.34 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171459
Assembly 2
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Multimeric state: hetero tetramer
Accessible surface area: 21831.85 Å2
Buried surface area: 3469.49 Å2
Dissociation area: 1,734.74 Å2
Dissociation energy (ΔGdiss): -3.6 kcal/mol
Dissociation entropy (TΔSdiss): 25.5 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-171460

Macromolecules

Chain: A
Length: 261 amino acids
Theoretical weight: 29.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WTS6 (Residues: 110-366; Coverage: 70%)
Gene names: KIAA1717, KMT7, SET7, SET9, SETD7
Pfam:
InterPro:
CATH:

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Chain: B
Length: 11 amino acids
Theoretical weight: 1.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q12962 (Residues: 186-195; Coverage: 5%)
Gene names: TAF10, TAF2A, TAF2H, TAFII30

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