4j56

X-ray diffraction
2.37Å resolution

Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thioredoxin reductase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 541 amino acids
Theoretical weight: 59.75 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: P61076 (Residues: 77-617; Coverage: 88%)
Gene names: PFI1170c, trxr2
Sequence domains:
Structure domains:
Thioredoxin Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 114 amino acids
Theoretical weight: 12.85 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7KQL8 (Residues: 2-104; Coverage: 99%)
Gene name: PF14_0545
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments


Cofactor: Ligand FAD 4 x FAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 101.88Å b: 89.18Å c: 151.33Å
α: 90° β: 91.62° γ: 90°
R-values:
R R work R free
0.238 0.236 0.259
Expression system: Escherichia coli