PDBe 4j2j

X-ray diffraction
2.5Å resolution

Crystal structure of AXH domain complex with Capicua

Released:

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ataxin-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 129 amino acids
Theoretical weight: 14.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54253 (Residues: 562-688; Coverage: 16%)
Gene names: ATX1, ATXN1, SCA1
Sequence domains: Ataxin-1 and HBP1 module (AXH)
Protein capicua homolog Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 21 amino acids
Theoretical weight: 2.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RK0 (Residues: 28-48; Coverage: 1%)
Gene names: CIC, KIAA0306

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: I222
Unit cell:
a: 77.722Å b: 89.096Å c: 132.663Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.27
Expression system: Escherichia coli