X-ray diffraction
2.8Å resolution

Crystal Structure of Fe(II)-HppE with alternative substrate (S)-1-HPP


Function and Biology Details

Reaction catalysed:
(S)-2-hydroxypropylphosphonate + H(2)O(2) = (1R,2S)-1,2-epoxypropylphosphonate + 2 H(2)O
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
(S)-2-hydroxypropylphosphonic acid epoxidase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 197 amino acids
Theoretical weight: 21.23 KDa
Source organism: Streptomyces wedmorensis
Expression system: Escherichia coli
  • Canonical: Q56185 (Residues: 2-198; Coverage: 100%)
Gene names: fom4, hppE
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P42212
Unit cell:
a: 111.456Å b: 111.456Å c: 151.419Å
α: 90° β: 90° γ: 90°
R R work R free
0.251 0.251 0.267
Expression system: Escherichia coli